This photomicrograph accompanied the May 2005 issue of Nature Medicine, bringing attention to an article by Wang and colleagues on the prevention of ataxia and cerebellar defects in a mouse model of Nijmegen breakage syndrome.

The cover image, courtesy of NCMIR's Thomas Deerinck and Mark Ellisman, University of California, San Diego depicts two-photon fluorescence microscopy of a mouse cerebellum section immuno-stained for the inositol 1,4,5- trisphosphate receptor (concentrated in Purkinje neurons; green), actin (red) and DNA in cell nuclei (blue).