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National Center for Microscopy and Imaging Research (NCMIR) Center for Research in
Biological Systems
Basic Science Building, Room 1000
University of California, San Diego
9500 Gilman Drive
Dept. Code 0608
La Jolla, CA 92093-0608 USA
Voice: (858) 534-0276
Fax: (858) 534-7497
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Research Excellence
The National Center for Microscopy and Imaging Research (NCMIR) at the University of California San Diego develops state-of-the-art 3D imaging and analysis technologies to help biomedical researchers understand biological structure and function relationships in cells and tissues in the dimensional range between 5 nm3 and 50 µm3. more

Chloroplast Tomogram

NCMIR releases an upgraded version of the Cell Centered Database: http://ccdb.ucsd.edu.
Read article
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NCMIR collaborators reveal how new neurons, born in the hippocampus, wire into the brain’s circuitry. Read article

NCMIR in the News
NCMIR Researcher is Helping to Bridge Art and Science Through the Use of Dynamic Media
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August 3 , 2007 -- Ruth West, director of visual analytics and interactive technologies at NCMIR and a team of engineers, computer scientists, biologists, and artists have created interactive artwork for exploring new ways of representing nature in the era of metagenomics. Viewers can interact real-time with genetic sequences of marine microorganism on CalIT2’s 100-million-pixel autosterographic display. The immersive visualization display is titled ATLAS in silico and is on display August 4-6 at UCSD’s CalIT2 as part of the annual SIGGRAPH conference. Read article

UCSD to Acquire Cutting-Edge Electron Microscope for Biomedical Research
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June 12, 2007 -- UCSD’s National Center for Microscopy and Imaging Research (NCMIR) has been awarded a large grant to assist in the purchase of a new high energy electron microscope. Today’s announcement by the National Center for Research Resources (NCRR), a part of the National Institutes of Health (NIH), will afford NCMIR scientists an opportunity to explore new microscope technologies for advancing research benefiting biomedical research. UCSD’s award is the only grant this year for an advanced electron microscope from NIH’s High-End Instrumentation (HEI) program. Read article

NCMIR scientist selected to judge the annual Nikon Small World Photomicrography Competition
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May 1 , 2007 -- Nikon Instruments Inc. has announced the judging panel for the 33rd International Small World Photomicrography Competition. The panel includes Thomas Deerinck, a Research Scientist at the National Center for Microscopy and Imaging Research at UCSD. The other judges chosen by Nikon for this year’s competition include John Hart, an Atmospheric and Oceanic Science Professor at University of Colorado; Malcolm Ritter, AP Science Writer; Daniel Sieberg, Science & Technology correspondent for CBS News; and Nicole Dyer, Senior Editor at Popular Science. Read article

NCMIR scientist wins first place in the 2006 Olympus BioScapes International Digital Imaging Competition
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December 10 , 2006 -- A strikingly colorful light microscopic image of mouse retina has earned first place for NCMIR scientist Thomas Deerinck in the 2006 Olympus BioScapes Digital Imaging Competition.  The quadruple-fluorescence confocal image, taken as part of a study on neurofibromatosis, shows the highly complex organization of some of the different cell types present in the retina. Read article

Collaborators from NBCR, CalIT2, EVL, and NCMIR to demonstrate integrated environment for the development of multiscale, multimodal, multi-site science at SC06
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November 1, 2006 -- Collaborators from the National Biomedical Computation Resource (NBCR), the California Institute for Telecommunications and Information Technology (CalIT2), the University of Illinois' Electronic Visualization Laboratory (EVL), and NCMIR will demonstrate how researchers at multiple locations can take advantage of advanced networks, software, and computational resources to extend the capabilities of bioscience instrumentation and informatics. The event is planned for the Tampa Convention Center during this year’s Super Computing Conference. Read article

Ellisman presents NCMIR Research to Japanese Royals
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September 6, 2006 -- Mark Ellisman presented an overview of NCMIR's collaborative research on multi-scale imaging and multi-scale modeling of the nervous system to Japan's Emperor Akihito and Empress Michiko. The occasion was at the invitation of the Emperor during the International Microscopy Congress, held in Sapporo,. Read article

NCMIR's Telescience featured in Science Grid this Week
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August 2, 2006 -- The online newsletter, Science Grid This Week, features Abel LIn's article, "From Microscopes to Middleware," describing how the Telescience Project started over a decade ago as an effort to make rare scientific instruments globally accessible. Read article

Science Reviews Fluorescent Probes for Studying Proteins
Cells in the Limelight

April-2006 -- UCSD scientists chart rapid advances of fluorescent tools for life-science research--Techniques promise to illuminate details of protein expression, activity and function. An interdisciplinary team of biological imaging experts from the UC San Diego has published a review in the journal Science of fluorescent imaging technologies and underscored the importance of those technologies to major advances in the life sciences...Read article

IBM’s online series highlights NCMIR’s Telescience technologies
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February 2006 -- NCMIR’s Abel Lin has authored a tutorial, “Building a Unified Grid” for IBM’s authoritative online reference, DeveloperWorks,  In this multi-part series, Lin details how Telescience’s Grid-based system architecture for science, developed at NCMIR over the past 20 years, is helping to blaze trails for Grid-developers outside of the ivory tower. Read article


 
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Mission Scientist sitting at the IVEM microscope
The mission of The National Center for Microscopy and Imaging Research (NCMIR) is to develop technologies to bridge understanding of biological systems between the gross anatomical and molecular scales and to make these technologies broadly available to biomedical researchers. more

NCMIR Offers
As a technology development center and P41 resource, NCMIR makes available for use intermediate voltage electron microscopes (IVEMs) and associated technologies for correlated microscopy, 3D reconstruction, and visualization, as well as advice and training in the application of these technologies. more

View a comprehensive listing of NCMIR resources here.

The facilities are open to visiting scientists through our collaborative, service, and training programs. Those interested in using NCMIR technologies should refer to the User Application form.

Collaboration and Service
NCMIR delivers advanced capabilities to the biomedical research community through interfacing of custom designed intermediate voltage electron microscopes (IVEMs) and light microscopes with advanced computational and graphics facilities. Technology development is driven by the needs of specific biological projects for specimen preparation, 3D investigations, and enhancement of microscopic imaging modes or computational tools. Biological projects are brought to NCMIR through an expanding collaborative research program. more
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Updated June 22, 2004